Is anyone taking Cobenfy, the new schizophrenia medication?

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donnie

New member
Cobenfy is a new schizophrenia medication approved by the FDA in September 2024 that targets acetylcholine receptors, unlike older anti-psychotic drugs that primarily target dopamine. This novel mechanism is designed to improve positive and negative symptoms while minimizing side effects like motor problems and sedation. It is a combination of xanomeline and trospium chloride, which also helps improve cognitive and negative symptoms, and was developed with contributions from researchers at Monash University.

Discuss in this thread your experiences with Cobenfy.
 

Jacob a popular YouTuber has tried Cobenfy he talks about it in the video above. According to him, the side effects kicked his ass. It always seems to be the case though with anti-psychotic drugs. Fortunately, however, weight gain is not an issue on it.
 
The side effects eventually lead me to coming off of it. I took it for about 200 or so days and then had to come off. It made me gain weight and also the heartburn was out of this world, as well as the nausea. Pulling over to the side of the road to throw up is not my definition of a good, or okay, time.
 
Oh yeah!! I had the bladder emptying problem in the beginning but that went away. So did the dizziness.
 
tarymst said:
The side effects eventually lead me to coming off of it. I took it for about 200 or so days and then had to come off. It made me gain weight and also the heartburn was out of this world, as well as the nausea. Pulling over to the side of the road to throw up is not my definition of a good, or okay, time.
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Gosh, that sounds miserable. I hope you're doing better now. You're also very strong for pushing through with it as long as you did.
 
Honestly, I haven't expected Cobenfy to be as able to create a unique environment as it has, especially since Cobenfy is an acetylcholine-acting medication rather than a dopamine-acting medication. Although I am still experiencing some level of sedation, at least I am not feeling the same "foggy" sensation that I had with older medications. Additionally, the improvement in motivation/clarity is another major factor that I find to be a significant change.
 
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