Why is clozapine used for treatment resistant schizophrenia?

invalid@example.com (donnie), donnie
Wed, 03 Dec 2025 08:50:40 +0000
General Medication Discussion

Clozapine is used for treatment-resistant schizophrenia and schizoaffective disorder because it is the only antipsychotic with proven effectiveness for this condition, due to its unique multi-receptor mechanism of action that includes a broader range of effects on dopamine, serotonin, and muscarinic receptors. Its effectiveness in treating both positive and negative symptoms, reducing suicidal behavior, and its lower propensity for causing extrapyramidal side effects compared to other...